Key result
Smooth-muscle cells from rat mesenteric resistance arteries possess a novel cGMP-dependent calcium-activated chloride current that is activated by intracellular calcium release.
Population
Freshly isolated smooth-muscle cells from rat mesenteric resistance arteries
Comparison
Elevation of intracellular calcium and… vs Pulmonary myocytes
Design
Preclinical
Authors
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No immediate clinical implications; leaves open a novel ion channel target for human vascular tone regulation.
Rat mesenteric resistance arteries contain a novel cGMP-dependent calcium-activated chloride current that is distinct from previously described calcium-activated chloride currents.
Matchkov et al. (2004) studied this question. Elevation of intracellular calcium and cGMP was evaluated on Characteristics of the calcium-activated chloride current. Smooth-muscle cells from rat mesenteric resistance arteries possess a novel cGMP-dependent calcium-activated chloride current that is activated by intracellular calcium release.
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