Why the study?
Do cyclic nucleotides and forskolin inhibit the slow inward calcium current in A7r5 vascular smooth muscle cells?
Population
Cultured A7r5 cells, a clonal cell line derived from rat aorta
Comparison
Application of cyclic nucleotides or forskolin /… vs Time-control group
Design
Preclinical
Follow-up
5 to 15 minutes
Authors
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Does not inform clinical practice; leaves open whether cAMP/cGMP effects on ICa extend to human vascular tone.
Do cyclic nucleotides and forskolin inhibit the slow inward calcium current in A7r5 vascular smooth muscle cells?
Cyclic nucleotides (cAMP and cGMP) and forskolin significantly inhibit the slow inward calcium current in cultured A7r5 vascular smooth muscle cells.
Lorenz et al. (1994) studied this question.
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