Key result
In rat aortic smooth muscle cells, K(ATP) channels are modulated by Ca2+ at physiological ATP levels via protein phosphatase type 2B, with maximal activation at 10 nmol/L intracellular Ca2+.
Why the study?
Does calcium modulate ATP-sensitive K+ channels in vascular smooth muscle cells?
Population
Rat aortic smooth muscle cells
Comparison
Modulation of intracellular and extracellular… vs Control recording conditions
Design
Preclinical
Authors
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Does not support altering clinical practice; leaves open whether Ca2+ modulates human vascular K(ATP) channels via protein phosphatase 2B.
Does calcium modulate ATP-sensitive K+ channels in vascular smooth muscle cells?
This study demonstrates for the first time that vascular smooth muscle K(ATP) channels are modulated by intracellular calcium at physiological ATP levels via protein phosphatase type 2B.
Wilson et al. (2000) studied this question. Intracellular Ca2+ modulation was evaluated on Whole-cell K(ATP) current. In rat aortic smooth muscle cells, K(ATP) channels are modulated by Ca2+ at physiological ATP levels via protein phosphatase type 2B, with maximal activation at 10 nmol/L intracellular Ca2+.
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