September 1, 1993AJP Cell Physiology

ATP-sensitive K+ channels in rat aorta and brain microvascular endothelial cells

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Population

Rat aorta and brain microvascular endothelial cells

Design

Preclinical

Authors

DJDamir JanigroCase Western Reserve University GWG. Alexander WestHouston Methodist EGE. L. GordonUniversity of Chicago

Discussion

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Implication

Endothelial KATP channels may sense metabolic stress in rats; leaves open any role in human vascular disease.

Structured PICO

Population

Rat aorta and brain microvascular endothelial cells

Intervention

Intracellular dialysis of ATP, glucose-free/NaCN (2 mM) solutions, glibenclamide (1-100 microM), pinacidil (30 microM), and ATP (10 microM-1 mM)

Outcome

Electrophysiological properties of ATP-sensitive K+ conductance (whole cell and single-channel currents)surrogate

Rat aorta and brain microvascular endothelial cells express KATP channels, which may play a role in regulating endothelial cell resting potential during impaired energy supply and modulating EDRF release.

Cite This Study

Janigro et al. (1993) studied this question.

synapsesocial.com/papers/6a8544869df997f4bbd6a46c https://doi.org/10.1152/ajpcell.1993.265.3.c812

View Full Paper

Ask AI

Bookmark

ATP-sensitive K+ channels in rat aorta and brain microvascular endothelial cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ATP-sensitive K+ channels in rat aorta and brain microvascular endothelial cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider