February 15, 1994The Journal of PhysiologyOpen Access

Calcitonin gene‐related peptide activated ATP‐sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A.

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Population

Smooth muscle cells enzymatically isolated from rabbit mesenteric arteries

Comparison

Calcitonin gene-related peptide and various… vs Control conditions

Design

Preclinical

Authors

Discussion

Findings from this animal model should not yet change practice; leaves open CGRP-PKA-KATP translation to human vascular disease.

Population

Smooth muscle cells enzymatically isolated from rabbit mesenteric arteries

Intervention

Calcitonin gene-related peptide (CGRP) (10 nM) and various pharmacological modulators (forskolin, Sp-cAMPS, protein kinase A inhibitors)

Comparator

Control conditions (absence of CGRP or presence of inhibitors)

Outcome

Activation of glibenclamide-sensitive whole-cell K+ currents measured via patch clampsurrogate

CGRP activates ATP-sensitive K+ channels in arterial smooth muscle through a cAMP and protein kinase A-dependent pathway.

Quayle et al. (1994) studied this question.

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