Key result
Depletion of intracellular Ca2+ stores by thapsigargin or BAPTA activates 3-pS nonselective cation channels in intact vascular smooth muscle cells.
Population
Vascular smooth muscle cells (SMC)
Comparison
Depletion of intracellular Ca2+ stores using… vs Resting SMC or application of second messengers
Design
Preclinical
Authors
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May inform vascular tone mechanisms in animal models; leaves open relevance to human disease or therapy.
Identifies and characterizes a 3-pS nonselective cation channel activated by Ca2+ store depletion in vascular smooth muscle cells, providing a mechanism for capacitative Ca2+ influx and regulation of vascular tone.
Trepakova et al. (2001) studied this question. Thapsigargin (TG) or BAPTA was evaluated on Activation of 3-pS cation channels. Depletion of intracellular Ca2+ stores by thapsigargin or BAPTA activates 3-pS nonselective cation channels in intact vascular smooth muscle cells.
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