Key result
In rat pulmonary artery smooth muscle cells, store depletion by cyclopiazonic acid activates cation channels, leading to Ca2+ influx and sustained contraction.
Population
Intact rat pulmonary artery rings and freshly isolated pulmonary artery smooth muscle cells (PASMCs)
Design
Preclinical
Authors
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Hypothesis-generating in rat cells; leaves open whether store-operated channels contribute to human pulmonary hypertension.
Store-operated channels, potentially involving Trp subunits, mediate Ca2+ influx and contraction in rat pulmonary artery smooth muscle cells following Ca2+ store depletion.
Ng et al. (2001) studied this question. Cyclopiazonic acid (CPA) was evaluated on Ca2+ influx and contraction. In rat pulmonary artery smooth muscle cells, store depletion by cyclopiazonic acid activates cation channels, leading to Ca2+ influx and sustained contraction.
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