Population
Arteries and arterioles from rat, guinea-pig, dog, and rabbit
Comparison
Modulation of sarcoplasmic reticulum Ca2+ stores… vs Phenylephrine in Ca2+-free medium without…
Design
Preclinical
Authors
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Highlights vessel-size differences in Ca2+ store dependence; leaves open translation to human vascular therapies.
The role of the sarcoplasmic reticulum in maintaining vascular contractility diminishes as arteries become smaller, with plasma membrane Ca2+ fluxes predominating in smaller vessels.
Low et al. (1996) studied this question.
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