October 1, 2001AJP Heart and Circulatory PhysiologyOpen Access

Role of sarcoplasmic reticulum in regulation of tonic contraction of rabbit basilar artery

View Full Paper

Ask AI

Bookmark

Population

Rabbit basilar artery

Design

Preclinical

Authors

TSTania SzadoRoche (Switzerland)MMMegan E. McLarnonSimon Fraser University XWXiaodong WangSoochow University

Discussion

Member takes

Implication

Prompts study of SR pathways in cerebral vasoregulation; leaves open whether they represent viable targets in human disease.

Structured PICO

Population

Rabbit basilar artery

Intervention

SR-depleting agents (thapsigargin and ryanodine) and large conductance K(Ca) (BK(Ca)) blockers (iberiotoxin (IbTX) and tetraethylammonium ion (TEA))

Outcome

Force development and intracellular Ca(2+) concentration ([Ca(2+)](i))surrogate

The sarcoplasmic reticulum in rabbit cerebral arteries modulates smooth muscle constriction through both direct calcium handling and indirect mechanisms involving calcium-activated potassium channels.

Cite This Study

Szado et al. (2001) studied this question.

synapsesocial.com/papers/6a82c68cfdcaa17bff6d0f3c https://doi.org/10.1152/ajpheart.2001.281.4.h1481

View Full Paper

Ask AI

Bookmark

Role of sarcoplasmic reticulum in regulation of tonic contraction of rabbit basilar artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of sarcoplasmic reticulum in regulation of tonic contraction of rabbit basilar artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider