Key result
Arterial smooth muscle SR buffers calcium entry, with discharge lowering the influx threshold for contraction.
Why the study?
The role of the superficial sarcoplasmic reticulum in regulating calcium entry and force development in arterial smooth muscle was not fully understood.
Population
Arterial smooth muscle including skinned arterial smooth muscle cells
Comparison
Depletion of intracellular Ca pool using norepinephrine and caffeine versus Ca entry blockers D600 and La3+ and inositol-trisphosphate
Design
Preclinical experimental study
Authors
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Hypothesis-generating for arterial calcium regulation; human studies needed before clinical translation.
The superficial sarcoplasmic reticulum in arterial smooth muscle acts as a regulated buffer barrier to calcium entry, modulating force development.
Breemen et al. (1986) studied this question. Norepinephrine, caffeine, D600, La3+, and high K+ depolarization was evaluated on Tension dependence on Ca influx and SR discharge. The superficial sarcoplasmic reticulum of arterial smooth muscle functions as a regulated buffer barrier to calcium entry, with the degree of SR discharge relating to the depression of the calcium influx threshold for contraction.
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