August 1, 1999AJP Heart and Circulatory Physiology

Sarcoplasmic reticulum and endothelium independently regulate venous smooth muscle Ca2+iand contraction

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Population

Rings of rabbit facial vein (RFV)

Comparison

Depletion of sarcoplasmic reticulum Ca2+ by… vs Endothelium-intact RFV and RFV without…

Design

Preclinical

Authors

RLRégent LaporteUniversity of California, San Diego ILIsmail LaherUniversity of British Columbia

Discussion

Member takes

Implication

No clinical translation to venous disorders; leaves open SR Ca2+ and endothelial roles in human vascular regulation.

Structured PICO

Population

Rings of rabbit facial vein (RFV)

Intervention

Depletion of sarcoplasmic reticulum (SR) Ca2+ by caffeine, followed by 25 mM K+ physiological salt solution (25K-PSS), with or without cyclopiazonic acid (30 microM) and endothelium removal

Comparator

Endothelium-intact RFV and RFV without cyclopiazonic acid treatment

Outcome

Isometric contraction and smooth muscle intracellular free Ca2+ concentration ([Ca2+]i)surrogate

Sarcoplasmic reticulum Ca2+ uptake and the endothelium independently regulate intracellular calcium levels and contraction in rabbit facial veins.

Cite This Study

Laporte et al. (1999) studied this question.

synapsesocial.com/papers/6a7da2f01693de70af99a4d9 https://doi.org/10.1152/ajpheart.1999.277.2.h749

View Full Paper

Ask AI

Bookmark

Sarcoplasmic reticulum and endothelium independently regulate venous smooth muscle Ca2+iand contraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sarcoplasmic reticulum and endothelium independently regulate venous smooth muscle Ca2+iand contraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider