August 1, 1998The Journal of PhysiologyOpen Access

Contribution of sarcoplasmic reticular calcium to smooth muscle contractile activation: gestational dependence in isolated rat uterus

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Population

Isolated rat uterine smooth muscle (myometria) from pregnant and non-pregnant rats

Comparison

Ryanodine, cyclopiazonic acid, and… vs Baseline conditions and comparison between…

Design

Preclinical

Authors

MTMichael J. TaggartNewcastle University SWSusan WrayUniversity of Bern

Discussion

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Implication

Gestational SR Ca2+ mobilization changes may modulate myometrial contractility; leaves open translational relevance to human labor.

Structured PICO

Population

Isolated rat uterine smooth muscle (myometria) from pregnant and non-pregnant rats

Intervention

Ryanodine (1-50 microM), cyclopiazonic acid (CPA, 20 microM), and agonist-induced SR Ca2+ release in zero external Ca2+

Comparator

Baseline conditions and comparison between pregnant and non-pregnant rat myometria

Outcome

Cytosolic [Ca2+] ([Ca2+]i) and force transientssurrogate

Calcium-induced calcium release plays little role in SR Ca2+ release from the myometrium, but there are gestational-dependent alterations in SR Ca2+ mobilization contributing to contractile activation.

Cite This Study

Taggart et al. (1998) studied this question.

synapsesocial.com/papers/6a82c68cfdcaa17bff6d0f46 https://doi.org/10.1111/j.1469-7793.1998.133bi.x

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Contribution of sarcoplasmic reticular calcium to smooth muscle contractile activation: gestational dependence in isolated rat uterus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contribution of sarcoplasmic reticular calcium to smooth muscle contractile activation: gestational dependence in isolated rat uterus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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