August 1, 1999AJP Cell Physiology
Pregnant rat myometrial cells show heterogeneous ryanodine- and caffeine-sensitive calcium stores
Population
Rat myometrial smooth muscle cells (pregnant and non-pregnant)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports ryr3-focused Ca2+ studies in rodent myometrium; leaves open human uterine contractility relevance.
Structured PICO
P
Population
Rat myometrial smooth muscle cells (pregnant and non-pregnant)
I
Intervention
Ryanodine and caffeine (pharmacological probes for Ca2+ release)
O
Outcome
Expression of ryanodine receptor (ryr) mRNAs and functional intracellular Ca2+ releasesurrogate
This study demonstrates the existence of functional ryanodine- and caffeine-sensitive calcium stores in rat myometrial cells, predominantly encoded by ryr3, which remain unchanged during pregnancy.
Cite This Study
Martin et al. (1999) studied this question.