Key result
Multiple RyR subtypes (RyR1, RyR2, RyR3) are coexpressed and differentially distributed in peripheral and perinuclear regions of rat pulmonary arterial smooth muscle cells.
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Findings remain preclinical; leaves open whether RyR subtype distribution influences human pulmonary vascular function or disease.
Yang et al. (2005) studied this question. Multiple RyR subtypes (RyR1, RyR2, RyR3) are coexpressed and differentially distributed in peripheral and perinuclear regions of rat pulmonary arterial smooth muscle cells.
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