Key result
Pharmacological interventions and expression analysis revealed pronounced regional heterogeneity in the function and expression of ryanodine receptors between smooth muscle cells of feed arteries and arterioles.
Population
C57BL/6 mice (isolated pressurized feed arteries and downstream arterioles from the cremaster muscle)
Design
Preclinical
Authors
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Regional ryanodine receptor heterogeneity urges vessel-specific vascular studies; leaves open human translation and targeted therapies.
The study demonstrates pronounced regional heterogeneity in the function and expression of ryanodine receptors between smooth muscle cells of feed arteries and downstream arterioles in mice.
Westcott et al. (2012) studied Vasomotor control in murine arteries. Pharmacological antagonists of RyRs and IP3Rs was evaluated on Ca(2+) sparks, Ca(2+) waves, global Ca(2+), and myogenic tone. Pharmacological interventions and expression analysis revealed pronounced regional heterogeneity in the function and expression of ryanodine receptors between smooth muscle cells of feed arteries and arterioles.
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