Population
Freshly isolated myocytes of resistance-sized cerebral arteries from RyR3-deficient knockout mice and…
Comparison
RyR3 deficiency (knockout model) vs Wild-type mice
Design
Preclinical
Authors
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RyR3 modulates cerebral myogenic tone in mice; leaves open its relevance as a therapeutic target in human cerebrovascular disease.
RyR3 is part of the SR Ca2+ spark release unit and plays a specific molecular role in regulating STOC frequency and myogenic tone in mouse cerebral artery vascular smooth muscle cells.
Löhn et al. (2001) studied this question.
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