Key result
FKBP12.6 deletion altered the frequency, amplitude, and kinetics of spontaneous Ca2+ sparks and STOCs in smooth muscle cells, whereas RYR3 deletion had no significant effect compared to wild-type.
RYR2 proteins, modulated by FKBP12.6, play a critical role in the formation of spontaneous and evoked Ca2+ sparks in smooth muscle cells.
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Animal data on FKBP12.6 and smooth muscle Ca2+ sparks should not change practice; leaves open human translation.
Ji et al. (2004) studied this question. FKBP12.6 and RYR3 gene deletion vs. Wild-type was evaluated on Spontaneous transient outward currents (STOCs), Ca2+ sparks, Ca2+-induced Ca2+ release, and Ca2+ waves. FKBP12.6 deletion altered the frequency, amplitude, and kinetics of spontaneous Ca2+ sparks and STOCs in smooth muscle cells, whereas RYR3 deletion had no significant effect compared to wild-type.
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