What does this research mean for the field?

Cardiac ryanodine receptors (RyR2s) physically couple to exhibit simultaneous 'coupled gating,' a coordinated behavior that is functionally dependent on the regulatory subunit FKBP12.6. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 8, 2001Circulation ResearchOpen Access

Coupled Gating Between Cardiac Calcium Release Channels (Ryanodine Receptors)

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Structured PICO

Population

Isolated cardiac calcium release channels/type 2 ryanodine receptors (RyR2s)

Intervention

Removal of the regulatory subunit, FK506 binding protein (FKBP12.6)

Comparator

Intact RyR2 channels with FKBP12.6

Outcome

Simultaneous gating (coupled gating) of multiple RyR2 channels in planar lipid bilayers

Coupled gating between RyR2 channels, regulated by FKBP12.6, may be a key mechanism in cardiac excitation-contraction coupling.

Discussion

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Implication

May refine models of RyR2 coordination in EC coupling; leaves open its role in human arrhythmias or HF.

Cite This Study

Marx et al. (2001) studied this question.

synapsesocial.com/papers/6a1a8f7fe916fa6dd3b8bdaf https://doi.org/10.1161/hh1101.091268

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Coupled Gating Between Cardiac Calcium Release Channels (Ryanodine Receptors)

Structured PICO

Discussion

Implication

Cite This Study

Coupled Gating Between Cardiac Calcium Release Channels (Ryanodine Receptors)

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider