Key result
FKBP proteins coordinate the coupled gating of ryanodine receptor channels, while PKA hyperphosphorylation in failing hearts depletes FKBP12.6 and impairs excitation-contraction coupling.
The FKBP-RyR interaction is essential for coupled gating of calcium release channels and represents a potential pharmacologic target for restoring function in heart failure.
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May support FKBP-targeted therapies in HF; leaves open whether restoring ryanodine receptor gating improves clinical outcomes.
Lehnart et al. (2003) conducted a review in Heart failure. FKBP-RyR interaction was evaluated. FKBP proteins coordinate the coupled gating of ryanodine receptor channels, while PKA hyperphosphorylation in failing hearts depletes FKBP12.6 and impairs excitation-contraction coupling.
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