Population
Basic science review focusing on the cardiac isoform of the ryanodine receptor and its regulatory proteins.
Design
Review
Authors
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RyR Ca2+ release demands cell-specific tuning; leaves open how regulators alter cardiac outcomes in disease.
This review summarizes the complex regulatory networks governing RyR2 calcium release channels, highlighting the importance of phosphorylation in the context of heart failure and inherited arrhythmias.
O’Brien et al. (2015) studied this question.
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