Population
Skeletal muscles of adult mice
Comparison
Expression of exogenous RyR3 vs Expression of exogenous RyR1 or yellow…
Design
Preclinical
Authors
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RyR3-specific sparks may guide isoform-targeted research in muscle Ca2+ release; animal data leave open human relevance.
Voltage-controlled Ca2+ sparks in skeletal muscle specifically require the RyR3 isoform acting as a slave parajunctional cohort to a master junctional RyR1 channel.
Pouvreau et al. (2007) studied this question.
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