Postnatal maturation of excitation-contraction coupling in rat ventricle in relation to the subcellular localization and surface density of 1,4-dihydropyridine and ryanodine receptors.

Adult and neonatal rat ventricle tissue

Labeling of L-type Ca2+ channels and sarcoplasmic reticulum Ca2+ release channels with [3H](+)-PN200-110 and [3H]ryanodine, and mechanical studies with ryanodine and L-type channel inhibitors

Adult versus neonatal tissue

Subcellular localization and surface density of 1,4-dihydropyridine and ryanodine receptors, and mechanical response to inhibitorssurrogate