Key result
Basal L-type Ca2+ current density was lower in neonatal rat ventricular myocytes compared to adults (6.7 vs 7.8 pA/pF, p<0.05), with slower inactivation and occasional mode-2 behavior.
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Neonatal rat myocyte Ca2+ current differences warrant caution extrapolating adult data to pediatrics; leaves open human developmental electrophysiology mechanisms.
Absolute Event Rate: 6.7% vs 7.8%
p-value: p=< 0.05
Katsube et al. (1998) studied this question. Neonatal developmental stage vs. Adult developmental stage was evaluated on Basal ICa(L) density (pA/pF) (p=< 0.05). Basal L-type Ca2+ current density was lower in neonatal rat ventricular myocytes compared to adults (6.7 vs 7.8 pA/pF, p<0.05), with slower inactivation and occasional mode-2 behavior.
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