March 1, 1991Circulation ResearchOpen Access

Developmental changes in calcium currents of rabbit ventricular cells.

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Why the study?

Does postnatal development affect L-type Ca2+ current density and inactivation time in rabbit ventricular cells?

Population

Enzymatically isolated adult and newborn rabbit ventricular cells

Comparison

Whole-cell patch-clamp method to record L-type… vs Adult vs Newborn cells

Design

Preclinical

Authors

TOToshiyuki OsakaShizuoka Saiseikai General Hospital RJRonald W. JoynerUniversity of Iowa

Discussion

Member takes

Implication

May inform age-specific arrhythmia risk in neonates; leaves open translation from rabbit models to humans.

Structured PICO

Does postnatal development affect L-type Ca2+ current density and inactivation time in rabbit ventricular cells?

Population

Enzymatically isolated adult (AD) and newborn (NB) (1-3-day-old) rabbit ventricular cells (n=18 total; 11 AD, 7 NB)

Intervention

Whole-cell patch-clamp method to record L-type Ca2+ current (ICa)

Comparator

Adult vs Newborn cells

Outcome

ICa density and time to half inactivation (T 1/2)surrogate

L-type calcium current density increases and inactivation time shortens during postnatal development in rabbit ventricular cells.

Cite This Study

Osaka et al. (1991) studied this question.

synapsesocial.com/papers/6a2044e9b64142f67e45f3e4 https://doi.org/10.1161/01.res.68.3.788

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Developmental changes in calcium currents of rabbit ventricular cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Developmental changes in calcium currents of rabbit ventricular cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider