Key result
Advanced patch clamp techniques, such as dynamic clamp and automated patch clamp, have significantly expanded the capabilities and efficiency of cardiac cellular electrophysiology research.
Advanced patch clamp techniques expand the capabilities of cardiac cellular electrophysiology by enabling more physiological measurements and higher throughput.
May improve research efficiency without immediate clinical implications; leaves open the extent of translational impact from these techniques.
The patch clamp technique, developed in late 1970s, started a new period of experimental cardiac electrophysiology enabling measurement of ionic currents on isolated cardiomyocytes down to the level of single channels. Since that time, the technique has been substantially improved by development of several upgraded modifications providing so far unavailable data (e.g. action potential clamp, dynamic clamp, high-resolution scanning patch clamp), or facilitating the patch clamp technique by increasing its efficiency (planar patch clamp, automated patch clamp). The current review summarizes the leading new patch clamp based techniques used in cardiac cellular electrophysiology, their principles and prominent related papers.
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Markéta Bébarová (2012) conducted a review in Cardiac cellular electrophysiology. Advanced patch clamp techniques was evaluated. Advanced patch clamp techniques, such as dynamic clamp and automated patch clamp, have significantly expanded the capabilities and efficiency of cardiac cellular electrophysiology research.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: