Key result
Apolipoprotein E epsilon4 genotype was significantly associated with unfavorable 6-month neurological outcome after aneurysmal subarachnoid hemorrhage (OR 11.3; 95% CI 2.2-57.0; P=0.003).
Why the study?
Does the apolipoprotein E epsilon4 genotype predict poor 6-month neurological outcome in patients with aneurysmal subarachnoid hemorrhage?
Population
72 patients with spontaneous aneurysmal subarachnoid hemorrhage, mean age 58.3 years, admitted to a single…
Comparison
Presence of apolipoprotein E epsilon4 genotype vs Absence of apolipoprotein E epsilon4 genotype
Design
Cohort
Follow-up
6 months
Authors
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May support risk stratification after aSAH; hypothesis-generating and should not yet change practice.
Cohort (n=72)
No
Does the apolipoprotein E epsilon4 genotype predict poor 6-month neurological outcome in patients with aneurysmal subarachnoid hemorrhage?
Odds Ratio: 11.3 (95% CI 2.2–57)
p-value: p=0.003
The apolipoprotein E epsilon4 genotype is a strong independent predictor of poor 6-month neurological outcome in patients with aneurysmal subarachnoid hemorrhage.
Leung et al. (2002) conducted a cohort in Aneurysmal subarachnoid hemorrhage (n=72). Apolipoprotein E epsilon4 genotype vs. Absence of apolipoprotein E epsilon4 genotype was evaluated on Unfavorable outcome at 6 months (Glasgow Outcome Scale score <= 3) (OR 11.3, 95% CI 2.2-57.0, p=0.003). Apolipoprotein E epsilon4 genotype was significantly associated with unfavorable 6-month neurological outcome after aneurysmal subarachnoid hemorrhage (OR 11.3; 95% CI 2.2-57.0; P=0.003).
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