The ESAS-score: A histological severity grading system of subarachnoid hemorrhage using the modified double hemorrhage model in rats

Fig 1. Grade I: A section of brain surface with no visible blood within the subarachnoid space (two blue arrows are marking the subarachnoid space).

Fig 2. Grade II: A section of brain surface showing the surrounding subarachnoid space with a thin layer of subarachnoid blood visible within the subarachnoid space (long striped arrow pointing at the subarachnoid space, short striped arrow pointing at a thin layer of subarachnoid blood, long blue arrow pointing at a vessel within the subarachnoid space and short blue arrow pointing at the arachnoidea).

Fig 3. Grade III: A section of brain surface showing the surrounding subarachnoid space with a thick local layer of subarachnoid blood visible within the subarachnoid space (short blue arrow pointing at the arachnoidea, long blue arrow pointing at the a thik blood layed within the subarachnoid space).

Fig 4. Grade IV: Section of the fourt ventricle with the choroidal plexus and diffuse blood clot visible within the ventricular cavity (long blue arrow pointing at the coroidal pexus and short blue arrow pointing at the blood clot within the ventricular cavity of the fourth ventricle).

Fig 5. A section of brain surface showing the surrounding subarachnoid space with slight meningeal reaction and local mild meningeal cell proliferation induced by SAH (long blue arrow pointing at a vessel wihtin the subarachnoid space and short blue arrow pointing at the meninges with local meningeal cell proliferation).

Fig 6. A section of brain surface showing the surrounding subarachnoid space with pronounced meningeal reaction and diffuse severe meningeal cell proliferation induced by SAH (short blue arrow pointing at the arachnoidea and long blue arrow pointing at diffuse meningeal cell proliferation within the subarachnoid space).

Fig 7. Meningeal reaction versus ESAS-score.

Fig 8. Neuroscore versus ESAS-score.