Key result
Iron overload augmented cardiac fibrosis and promoted neointima formation in angiotensin II-infused rats, while iron chelation with deferoxamine significantly reduced cardiac fibrosis.
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May reduce fibrosis in iron-overloaded hypertensive hearts; leaves open clinical translation of deferoxamine.
Ishizaka et al. (2002) studied Angiotensin II-induced cardiac injury. Iron overload (iron-dextran) or iron chelation (deferoxamine) vs. Untreated rats or norepinephrine-infused rats was evaluated on Cardiac fibrosis and neointima formation. Iron overload augmented cardiac fibrosis and promoted neointima formation in angiotensin II-infused rats, while iron chelation with deferoxamine significantly reduced cardiac fibrosis.
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