Key result
A 4-day-old boy developed myocarditis and a persistent left ventricular aneurysm following coxsackievirus B1 meningitis despite receiving intravenous immunoglobulin treatment.
Case Report (n=1)
Highlights the risk of myocarditis developing after enteroviral meningitis in neonates despite standard IVIG therapy, suggesting a potential role for high-dose IVIG.
Neonates with enteroviral meningitis need close cardiac monitoring post-IVIG; this case leaves open whether higher-dose regimens reduce aneurysm risk.
Enteroviral infection is one of the most common neonatal infections, and most patients recover without complications. This report describes a neonate who experienced meningitis followed by myocarditis. A 4-day-old boy was admitted with fever, diagnosed with enteroviral meningitis and treated with intravenous immunoglobulin (IVIG). However, myocarditis was subsequently diagnosed in spite of IVIG treatment, and coxsackievirus B1 (CXB1) was revealed as a cause. A left ventricular aneurysm persisted even though the patient recovered with repeated high-dose IVIG treatment and cardiac supportive care. This report describes a rare case where myocarditis developed several days after a diagnosis of CXB1 meningitis in spite of IVIG treatment. It is important to pay attention to the patient's clinical condition until the end of the second viremia of enterovirus and to consider high-dose IVIG treatment when treating enteroviral infections for neonates.
No takes yet. Share an insight, caveat, or question.
Bae et al. (2013) conducted a case report in Neonatal meningitis and myocarditis caused by Coxsackievirus B1 (n=1). Intravenous immunoglobulin (IVIG) was evaluated on Development of myocarditis and left ventricular aneurysm. A 4-day-old boy developed myocarditis and a persistent left ventricular aneurysm following coxsackievirus B1 meningitis despite receiving intravenous immunoglobulin treatment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: