Key result
Magnetic resonance imaging and spectroscopy offer multiple potential biomarkers for diagnosing and monitoring disease severity in muscular dystrophies by detecting small increments of disease-related change.
Why the study?
With progress in identifying genetic muscle diseases and developing treatments, sensitive and objective new methods are required to identify and monitor muscle pathology.
Does magnetic resonance imaging provide sensitive and objective biomarkers for monitoring muscle pathology in patients with muscular dystrophy?
Does magnetic resonance imaging provide sensitive and objective biomarkers for monitoring muscle pathology in patients with muscular dystrophy?
MRI and spectroscopy provide sensitive, objective biomarkers for monitoring disease severity and progression in muscular dystrophies, which is crucial for evaluating emerging treatments.
Should not yet change clinical monitoring in muscular dystrophies; extends evidence for MRI biomarkers in research settings.
Recent years have seen steady progress in the identification of genetic muscle diseases as well as efforts to develop treatment for these diseases. Consequently, sensitive and objective new methods are required to identify and monitor muscle pathology. Magnetic resonance imaging offers multiple potential biomarkers of disease severity in the muscular dystrophies. This Review uses a pathology-based approach to examine the ways in which MRI and spectroscopy have been used to study muscular dystrophies. Methods that have been used to quantitate intramuscular fat, edema, fiber orientation, metabolism, fibrosis, and vascular perfusion are examined, and this Review describes how MRI can help diagnose these conditions and improve upon existing muscle biomarkers by detecting small increments of disease-related change. Important challenges in the implementation of imaging biomarkers, such as standardization of protocols and validating imaging measurements with respect to clinical outcomes, are also described.
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Doris G. Leung (2019) conducted a review in Muscular dystrophy. Magnetic resonance imaging and spectroscopy was evaluated. Magnetic resonance imaging and spectroscopy offer multiple potential biomarkers for diagnosing and monitoring disease severity in muscular dystrophies by detecting small increments of disease-related change.
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