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The effect of antiarthritic drugs on a sulfhydryl-disulfide interchange reaction between rat serum sulfhydryl groups and dithiobisnitrobenzoic acid was determined. Gold sodium thiomalate and gold thioglucose produced potent, dose dependent inhibition of the interchange reaction. Thus, the interchange reaction utilizing rat serum appears to be a sensitive and quantitative procedure to measure the sulfhydryl group reactivity of potential antiarthritic agents.
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Walz et al. (1972) studied this question.
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