Key result
A theoretical pharmacogenomic test for preventing ACE inhibitor-induced angioedema is cost-effective at a €20,000/QALY threshold only if the test costs ≤€1.30, or ≤€5.03 in high-risk populations.
Why the study?
Is a theoretical pharmacogenomic test for preventing ACE inhibitor-induced angioedema cost-effective?
Is a theoretical pharmacogenomic test for preventing ACE inhibitor-induced angioedema cost-effective?
A theoretical pharmacogenomic test for ACE inhibitor-induced angioedema is only cost-effective if it has high sensitivity, high specificity, and a very low price, though targeting high-risk populations allows for a slightly higher test price.
AIM: To assess the required characteristics (cost, sensitivity and specificity) of a pharmacogenomic test for being a cost-effective prevention of angiotensin-converting enzyme inhibitors induced angioedema. Furthermore, we assessed the influence of only testing high-risk populations. MATERIALS & METHODS: A decision tree was used. RESULTS: With a willingness-to-pay threshold of €20,000 and €80,000 per quality adjusted life year, a 100% sensitive and specific test may have a maximum cost of €1.30 and €1.95, respectively. When only genotyping high-risk populations, the maximum test price would be €5.03 and €7.55, respectively. CONCLUSION: This theoretical pharmacogenomic test is only cost-effective at high specificity, high sensitivity and a low price. Only testing high-risk populations yields more realistic maximum test prices for cost-effectiveness of the intervention.
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Geenen et al. (2017) studied Angiotensin-converting enzyme inhibitors induced angioedema. Pharmacogenomic test was evaluated on Maximum cost for cost-effectiveness. A theoretical pharmacogenomic test for preventing ACE inhibitor-induced angioedema is cost-effective at a €20,000/QALY threshold only if the test costs ≤€1.30, or ≤€5.03 in high-risk populations.
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