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Five patients with megaloblastic anemia due to Vit. B12 and/or folic acid deficiency who excreted abnormally large quantities of formiminoglutamic acid (FGA) after a 20 g oral L-histidine · HCl load were studied. FGA excretion was markedly reduced in all 4 subjects given 20 g DL-methionine and in both subjects given 20 g glycine together with L-histidine · HCl. Of 3 subjects given 20 g DL-serine, one showed no reduction in FGA excretion and 2 showed moderate reduction.
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Herbert et al. (1963) studied this question.
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