Key result
Adenosine triphosphate and pyrophosphate prevented the loss of Ca-activated ATPase activity and transformation of myosin caused by high concentrations of mercurial sulfhydryl reagent.
Population
Myosin (in vitro biochemical model)
Comparison
Adenosine triphosphate and pyrophosphate vs High concentrations of mercurial sulfhydryl…
Design
Preclinical
Authors
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Supports conformational model of myosin sulfhydryl reactivity; hypothesis-generating for cardiac contractility with no clinical implications yet.
The findings support the hypothesis that the strategic sulfhydryl group initiates a conformational change upon reaction with mercurial reagent rather than binding ATP at the active site.
D.R. Kominz (1965) studied this question. Adenosine triphosphate and pyrophosphate was evaluated on Loss of Ca-activated adenosine triphosphatase activity and transformation of myosin. Adenosine triphosphate and pyrophosphate prevented the loss of Ca-activated ATPase activity and transformation of myosin caused by high concentrations of mercurial sulfhydryl reagent.
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