Key result
Inhibition of adenosinetriphosphatase by sulfhydryl reagents and reactivation by glutathione indicates it is a sulfhydryl enzyme, supporting the assumption that myosin and ATPase are identical.
Population
Myosin and adenosinetriphosphatase enzyme models
Design
Preclinical
Authors
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Supports myosin-ATPase identity in animal models; leaves open translation to human cardiac function or therapy.
This basic science study provides biochemical evidence that adenosinetriphosphatase is a sulfhydryl enzyme and supports the hypothesis that myosin and adenosinetriphosphatase are identical.
Singer et al. (1944) studied this question. Sulfhydryl reagents was evaluated on Adenosinetriphosphatase activity. Inhibition of adenosinetriphosphatase by sulfhydryl reagents and reactivation by glutathione indicates it is a sulfhydryl enzyme, supporting the assumption that myosin and ATPase are identical.
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