A novel mucoadhesive polymer was prepared by template polymerization of acrylic acid in the presence of sericin for a transmucosal drug-delivery (TMD) system. FTIR results indicated that a polymer complex was formed between poly(acrylic acid) (PAA) and sericin through hydrogen bonding. The glass transition temperatures (Tg's) of sericin and PAA in the PAA/sericin polymer complex were inner-shifted compared with the Tg's of sericin and PAA themselves. This may be due to the increased miscibility of PAA with sericin through hydrogen bonding. The dissolution rate of the PAA/sericin interpolymer complex was dependent on the pH. The mucoadhesive force of the PAA/sericin polymer complex was similar to that of a commercial product, Carbopol 971P NF.
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Ahn et al. (2001) studied this question.
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