Key result
Six patients from two families presented with an autosomal dominantly inherited myopathy characterized by stretch-induced rippling muscle contractions without accompanying action potentials.
Case Report (n=6)
This case series describes the clinical and biopsy findings of rippling muscle disease, suggesting an intracellular derangement in the muscle fiber.
Alerts clinicians to rare inherited rippling myopathy; leaves open causative genes and intracellular mechanisms for study.
Six patients from two families with an autosomal dominantly inherited disease, apparently a myopathy, are described. Their major complaint was muscle stiffness, primarily in the legs. The muscles displayed an unusual sensitivity to stretch, manifested by rippling waves of muscle contraction. These rippling contractions were not accompanied by muscle fiber action potentials. Nonspecific, mild abnormalities were seen on muscle biopsy. These findings raise the possibility that there is an intracellular derangement in the muscle fiber responsible for the muscle rippling; further studies are necessary to establish the underlying pathophysiologic condition.
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Ricker et al. (1989) conducted a case report in Rippling Muscle Disease (n=6). Autosomal dominantly inherited myopathy was evaluated on Clinical and biopsy findings. Six patients from two families presented with an autosomal dominantly inherited myopathy characterized by stretch-induced rippling muscle contractions without accompanying action potentials.
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