Key result
Postnatal human and murine epicardium contains c-kit(+) and CD34(+) cells with stem cell characteristics that proliferate and express cardiac and vascular markers following myocardial infarction.
The postnatal epicardium contains c-kit(+) and CD34(+) stem cells that proliferate and differentiate into vascular cells following myocardial infarction, suggesting a potential role in endogenous cardiac regeneration.
No takes yet. Share an insight, caveat, or question.
Remains preclinical; leaves open epicardial progenitors as a regenerative target post-MI pending human validation.
Limana et al. (2007) studied Myocardial infarction. Coronary ligation (murine model) was evaluated on Presence, proliferation, and differentiation of epicardial c-kit(+) and CD34(+) cells. Postnatal human and murine epicardium contains c-kit(+) and CD34(+) cells with stem cell characteristics that proliferate and express cardiac and vascular markers following myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: