Key result
Elderly patients with pulmonary arterial hypertension exhibited a distinct clinical profile, with mortality independently predicted by TAPSE (HR 1.272) and uric acid (HR 1.291) rather than classical markers.
Cohort (n=119)
No
Absolute Event Rate: 39.5% vs 36.8%
p-value: p=0.771
Elderly patients with precapillary PAH exhibit distinct clinical and hemodynamic profiles, as well as different prognostic markers for mortality, compared to younger patients.
BACKGROUNDS: Pulmonary arterial hypertension (PAH) was previously considered an illness that affects mostly the young, but now it is also increasingly recognized in the elderly. The aim of this study was to compare the features of elderly versus younger patients diagnosed with PAH, and to define the prognostic factors which affect their long-term survival. METHODS: In this prospective, single center study, the clinical, echocardiographic, hemodynamic characteristics, and the outcomes of younger (18-65 years) and elderly (≥ 65 years) patients with definitive diagnosis of precapillary PAH were compared. RESULTS: = 0.013) values were the only parameters associated with mortality. CONCLUSIONS: Our data suggest that elderly PAH patients have a unique clinical and hemodynamic profile, with totally different prognostic markers compared to younger PAH patients.
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Özpelit et al. (2017) conducted a cohort in Pulmonary arterial hypertension (n=119). Older age (≥ 65 years) vs. Younger age (< 65 years) was evaluated on All-cause mortality (p=0.771). Elderly patients with pulmonary arterial hypertension exhibited a distinct clinical profile, with mortality independently predicted by TAPSE (HR 1.272) and uric acid (HR 1.291) rather than classical markers.
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