The relative stabilities of the skeletal-muscle myosins of some animals

only if alkylation on each strand at nearly opposite points had occurred. At low degrees of alkylation by monofunctional agents this would occur only rarely, being in proportion to the square of the degree of alkylation; with difunctional agents about a quarter of the alkylations would be of this type. It would also be expected that fission of the DNA molecule could seriously interfere with its biological function.