Key result
Exosomal miR-155 significantly inhibited Enterovirus A71 infection both in vitro and in vivo by directly targeting and down-regulating phosphatidylinositol clathrin assembly protein (PICALM).
Why the study?
It is unclear how exosomal miRNAs regulate recipient cellular responses during EV-A71 infection.
Does exosomal miR-155 inhibit EV-A71 infection in preclinical models?
Population
EV-A71-infected patients and healthy individuals, along with in vitro and in vivo models
Comparison
Exosomal miR-155 vs control or EV-A71-infected vs healthy individuals
Design
Preclinical laboratory and in vivo translational study
Authors
Loading...
May inform antiviral strategies for EV-A71; hypothesis-generating from neonatal mouse data and requires clinical validation.
Does exosomal miR-155 inhibit EV-A71 infection in preclinical models?
Exosomal miR-155 inhibits EV-A71 infection by targeting PICALM, providing insights into the regulatory mechanisms of viral infection and a potential therapeutic target.
Wu et al. (2019) studied Enterovirus A71 infection. Exosomal miR-155 vs. Exosomal miR-mimic-NC was evaluated on EV-A71 viral genomic RNA and VP1 protein expression. Exosomal miR-155 significantly inhibited Enterovirus A71 infection both in vitro and in vivo by directly targeting and down-regulating phosphatidylinositol clathrin assembly protein (PICALM).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: