Key result
RIG-1 rs3739674 G vs C polymorphism was associated with an increased risk of EV71-induced HFMD in Chinese children (OR 1.502; 95% CI 1.120-2.014).
Case-Control (n=381)
Odds Ratio: 1.502 (95% CI 1.12–2.014)
RIG-1 and TLR3 polymorphisms are associated with susceptibility to and severity of EV71-induced hand, foot, and mouth disease in Chinese children, highlighting the role of innate immunity.
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May aid EV71 risk stratification in children; hypothesis-generating for innate immunity genetics, needs prospective validation.
Li et al. (2017) conducted a case-control in Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) (n=381). RIG-1 rs3739674 G vs C polymorphism vs. C allele / Controls was evaluated on Risk of EV71-induced HFMD (OR 1.502, 95% CI 1.120-2.014). RIG-1 rs3739674 G vs C polymorphism was associated with an increased risk of EV71-induced HFMD in Chinese children (OR 1.502; 95% CI 1.120-2.014).
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