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January 29, 2014PLoS ONEOpen Access

PolyC-Binding Protein 1 Interacts with 5′-Untranslated Region of Enterovirus 71 RNA in Membrane-Associated Complex to Facilitate Viral Replication

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Key result

PolyC-binding protein 1 (PCBP1) specifically binds to the 5'-untranslated region of Enterovirus 71 RNA in a membrane-associated complex to facilitate viral replication.

Population

Human embryonal rhabdomyosarcoma (RD), human neuroblastoma (SK-N-SH), and HeLa cell lines

Comparison

Enterovirus 71 infection and manipulation of… vs Mock-infected cells, control siRNA, or bovine…

Design

Preclinical

Authors

ZLZhen LuoXDXingchen DongYLYouxing Li

Discussion

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Overview

Supports PCBP1 as potential EV71 antiviral target; animal data leaves open clinical translation.

Structured PICO

P
Population
Human embryonal rhabdomyosarcoma (RD), human neuroblastoma (SK-N-SH), and HeLa cell lines
I
Intervention
Enterovirus 71 (EV71) infection and manipulation of PCBP1 expression (plasmids or siRNA)
C
Comparator
Mock-infected cells, control siRNA, or bovine serum albumin (BSA)
O
Outcome
Interaction between PCBP1 and EV71 5'UTR RNA and its role in viral replication

PCBP1 acts as a positive regulator of EV71 replication by binding to the 5'UTR of the viral RNA in a membrane-associated replication complex.

Cite This Study

Luo et al. (2014) studied Enterovirus 71 (EV71) infection. PolyC-Binding Protein 1 (PCBP1) was evaluated on Viral replication and protein expression. PolyC-binding protein 1 (PCBP1) specifically binds to the 5'-untranslated region of Enterovirus 71 RNA in a membrane-associated complex to facilitate viral replication.

synapsesocial.com/papers/6a978de8713b4e110fe334c7https://doi.org/10.1371/journal.pone.0087491
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation2008 · 148 citations
  2. 2The N-terminal K Homology Domain of the Poly(rC)-binding Protein Is a Major Determinant for Binding to the Poliovirus 5′-Untranslated Region and Acts as an Inhibitor of Viral Translation1999 · 71 citations
  3. 3The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms2002 · 482 citations
  4. 4Poliovirus 5′-Terminal Cloverleaf RNA Is Required in cis for VPg Uridylylation and the Initiation of Negative-Strand RNA Synthesis2001 · 94 citations
  5. 5Pathogenesis of Enterovirus 71 Brainstem Encephalitis in Pediatric Patients: Roles of Cytokines and Cellular Immune Activation in Patients with Pulmonary Edema2003 · 293 citations