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This review outlines methods for determining the heparin therapeutic range and provides recommendations for establishing an APTT heparin therapeutic range across all hospital sizes.
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This review provides recommendations for laboratories to establish an APTT heparin therapeutic range for monitoring unfractionated heparin therapy.
When administering unfractionated heparin (UFH), therapeutic levels of anticoagulation must be achieved rapidly and maintained consistently in the therapeutic range. The basic assays for monitoring UFH therapy are the activated partial thromboplastin time (APTT) and/or the chromogenic antifactor Xa or antithrombin assays. For many laboratories, the APTT is the preferred standard of practice; however, the APTT is a surrogate marker that only estimates the heparin concentration. Many factors, including patient variation, reagents of the APTT, UFH composition, and concentration can influence the APTT result. This article reviews various methods to determine the heparin therapeutic range and presents recommendations for the laboratory to establish an APTT heparin therapeutic range for all sizes of hospitals.
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Clément et al. (2016) conducted a review in Unfractionated heparin therapy monitoring. Activated partial thromboplastin time (APTT) monitoring was evaluated. This review outlines methods for determining the heparin therapeutic range and provides recommendations for establishing an APTT heparin therapeutic range across all hospital sizes.
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