Key result
Bicuspid aortic valve disease and ascending aortic dilation were associated with decreased plasma alpha-Tocopherol and increased C-reactive protein and endothelial microparticles.
Why the study?
BAV is associated with an increased risk of developing ascending aorta dilation, but currently no established risk biomarkers exist to facilitate the diagnosis and prognosis of BAV.
Observational (n=212)
Answers are grounded in this paper and cite their sources.
Decreased antioxidant capacity and increased inflammation and endothelial damage biomarkers are associated with bicuspid aortic valve disease and ascending aortic dilation.
BACKGROUND: The bicuspid aortic valve (BAV) is the most common cardiac congenital disease and is associated with an increased risk of developing ascending aorta dilation; which can have fatal consequences. Currently; no established risk biomarkers exist to facilitate the diagnosis and prognosis of BAV. METHODS: = 212), we analyzed the role possibly played by alpha-Tocopherol in BAV disease; considering its association with the pathophysiological characteristics of BAV and biomarkers related to inflammation, oxidative stress and endothelial damage, as well as characteristics related to alpha-Tocopherol functionality and metabolism. RESULTS: We found that BAV patients; especially those with ascending aortic dilation; presented lower antioxidant capacity; as determined by decreased plasma levels of alpha-Tocopherol; paraoxonase 1 and high-density lipoprotein (HDL), as well as increased levels of C-reactive protein (CRP; a biomarker of inflammation) and endothelial microparticles (EMPs; an endothelial damage biomarker). By applying random forest analyses; we evaluated the significant screening capacity of alpha-Tocopherol; CRP and EMPs to classify patients depending on the morphology of the aortic valve. DISCUSSION: Our findings support the role of decreased antioxidant capacity; increased inflammation and endothelial damage in the pathogenesis of BAV and the progression of aortic dilation. Moreover; determining the plasma levels of alpha-Tocopherol; CRP and EMPs could improve BAV diagnosis in large populations.
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Martínez-Micaelo et al. (2020) conducted an observational in Bicuspid aortic valve disease (n=212). Bicuspid aortic valve disease and ascending aortic dilation was evaluated on Antioxidant capacity and biomarker levels (alpha-Tocopherol, CRP, EMPs). Bicuspid aortic valve disease and ascending aortic dilation were associated with decreased plasma alpha-Tocopherol and increased C-reactive protein and endothelial microparticles.
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