Key result
Normal tension glaucoma was associated with a significant reduction in the standard deviation of normal-to-normal intervals compared to healthy controls.
Why the study?
Is normal tension glaucoma associated with altered short-term heart rate variability compared to healthy controls?
Case-Control (n=107)
Is normal tension glaucoma associated with altered short-term heart rate variability compared to healthy controls?
Normal tension glaucoma is associated with autonomic dysfunction, as evidenced by reduced heart rate variability and altered sympathovagal balance.
Answers are grounded in this paper and cite their sources.
May signal autonomic dysfunction in normal tension glaucoma; hypothesis-generating and requires prospective validation before clinical consideration.
INTRODUCTION: The purpose of this study was to investigate the dysfunction of autonomic control that may be a contributing factor in normal tension glaucoma (NTG) by showing the short-term heart rate variability in NTG patients. MATERIALS AND METHODS: Newly diagnosed NTG patients and an age-matched normal control group were enrolled in this prospective study. Blood pressure was obtained and the electrocardiogram was monitored for 5 minutes after 30-minute rest in a supine position. Electrocardiographic signals were transferred to a heart rate analyzer. The time and frequency domain parameters of heart rate variability were analyzed between two groups. RESULT: In all, 77 NTG patients and 30 healthy controls were included in the study. There were no significant differences between NTG and controls with respect to age, sex, and a hypertensive history, heart rate, systolic pressure, and diastolic pressure. NTG patients showed a significant reduction in the standard deviation of the mean of qualified normal-to-normal intervals in comparison with controls (27.64+/-10.90 vs. 36.22+/-10.21, P=0.041). Low-frequency values in NTG patients were statistically lower than in healthy controls (P=0.001) and the low-frequency/high-frequency ratio was significantly higher in the NTG group (P=0.000). DISCUSSION: Our study results showed that the dysfunction of an autonomic control is associated with NTG patients.
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Na et al. (2010) conducted a case-control in Normal tension glaucoma (NTG) (n=107). Normal tension glaucoma vs. Healthy controls was evaluated on Standard deviation of the mean of qualified normal-to-normal intervals (p=0.041). Normal tension glaucoma was associated with a significant reduction in the standard deviation of normal-to-normal intervals compared to healthy controls.
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