What question did this study set out to answer?

To determine the prevalence of amoebic colitis using an antigen-capture ELISA targeting Entamoeba histolytica in patients presenting with acute diarrhoea.

April 1, 2002Tropical Medicine & International HealthOpen Access

Diagnosis of amoebic colitis by antigen capture ELISA in patients presenting with acute diarrhoea in Cairo, Egypt

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To determine the prevalence of amoebic colitis using an antigen-capture ELISA targeting Entamoeba histolytica in patients presenting with acute diarrhoea.
Evaluated 84 consecutive patients presenting with acute diarrhoea (duration <1 week) at an outpatient tropical medicine clinic in Cairo, Egypt.
Included two comparison cohorts: 182 healthy regional controls and 64 controls with prolonged diarrhoea (duration >1 week).
Diagnosed amoebic colitis by detecting stool occult blood and the E. histolytica galactose-inhibitable lectin antigen via ELISA, supplemented by serum amoebic antibody testing.
Entamoeba histolytica infection occurred in 57.1% of acute diarrhoea patients compared with 21.4% of healthy controls and 25% of prolonged diarrhoea controls (P < 0.001).
Amoebic colitis was diagnosed in 38% (32/84) of acute diarrhoea patients, and 97% (31/32) of these individuals tested positive for serum amoebic antibodies (P < 0.001 vs. controls).
Nonpathogenic Entamoeba dispar infection was significantly less prevalent in acute diarrhoea cases (8.3%) than in healthy controls (24.2%, P = 0.004) or prolonged diarrhoea controls (20.3%, P = 0.061).

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Implication

Observational study reveals high amoebic colitis prevalence via antigen ELISA in acute diarrhoea patients, highlighting substantial Entamoeba histolytica burden.

Cite This Study

Abd‐Alla et al. (2002) studied this question.

synapsesocial.com/papers/6a979c8178a91a1f562d2018 https://doi.org/10.1046/j.1365-3156.2002.00862.x

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Implication

Observational study reveals high amoebic colitis prevalence via antigen ELISA in acute diarrhoea patients, highlighting substantial Entamoeba histolytica burden.

Diagnosis of amoebic colitis by antigen capture ELISA in patients presenting with acute diarrhoea in Cairo, Egypt

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Discussion

Implication

Cite This Study

Diagnosis of amoebic colitis by antigen capture ELISA in patients presenting with acute diarrhoea in Cairo, Egypt

Key Points

Discussion

Implication

Cite This Study

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