A rapid synthetic method for the preparation of polyamide dendrimer without protection and deprotection steps has been developed. A symmetrically branched third-generation polyamide dendrimer was prepared by a convergent method involving activation of focal point with a condensing agent, diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate (DBOP), followed by condensation of the active amide with the diaminocarboxylic acid 3,5-bis(4-aminophenoxy)benzoic acid as an AB2 building block.
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Okazaki et al. (2003) studied this question.
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