Key result
Pien Tze Huang exerted hepatoprotective effects in NASH mouse models by improving steatosis and fibrosis and reducing ALT and AST levels via suppression of the NF-κB pathway.
Why the study?
NAFLD is the most common liver disease and may progress to NASH, fibrosis, cirrhosis, and hepatocellular carcinoma, prompting investigation into the effects of Pien Tze Huang in preclinical NASH models.
Does Pien Tze Huang improve liver steatosis, fibrosis, and inflammation in NASH mouse models?
Does Pien Tze Huang improve liver steatosis, fibrosis, and inflammation in NASH mouse models?
Pien Tze Huang demonstrates hepatoprotective and anti-inflammatory effects in mouse models of NASH, primarily by suppressing the NF-κB pathway.
PTH hepatoprotection in mouse NASH models; leaves open translation to human disease.
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease that may progress to nonalcoholic steatohepatitis (NASH), hepatic tissue fibrosis, liver cirrhosis, and hepatocellular carcinoma. In this study, we investigated the effects of Pien Tze Huang (PTH), a well-known traditional Chinese herbal formula with liver protective effect, in methionine-choline deficient diet (MCD)- and high-fat diet (HFD)-induced NASH mouse models. Our results showed that PTH could exert hepatoprotective effects by improving liver weight and steatosis and reducing the fibrosis and serum levels of alanine transaminase (ALT) and aspartate transaminase (AST) in both animal models. The effects of PTH was accompanied with the reduction of infiltrated macrophages, the inhibition of the expression of cytokines, and the induction of adiponectin expression. Mechanistically, we found that PTH could inhibit the activation of proinflammatory transcription factor nuclear factor-κB (NF-κB) by preventing the degradation of inhibitor of κBα (IκBα). These results demonstrate that PTH can improve NAFLD largely due to its suppression of the NF-κB inflammatory pathway.
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Lian et al. (2022) studied Nonalcoholic fatty liver disease (NAFLD). Pien Tze Huang (PTH) was evaluated on Liver weight, steatosis, fibrosis, and serum levels of ALT and AST. Pien Tze Huang exerted hepatoprotective effects in NASH mouse models by improving steatosis and fibrosis and reducing ALT and AST levels via suppression of the NF-κB pathway.
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