Key result
An elevated Triglyceride-glucose (TyG) index was independently associated with an increased risk of severe acute pancreatitis (OR 1.513) and ICU admission (OR 1.358).
Why the study?
Data on the triglyceride-glucose index in acute pancreatitis were lacking, motivating an evaluation of its predictive value for the prognosis of severe acute pancreatitis.
Does an elevated TyG index predict severe disease, ICU admission, and mortality in patients with acute pancreatitis?
Cohort (n=404)
No
Does an elevated TyG index predict severe disease, ICU admission, and mortality in patients with acute pancreatitis?
An elevated Triglyceride-glucose (TyG) index at admission is an independent predictor of severe disease, ICU admission, and mortality in patients with acute pancreatitis.
Answers are grounded in this paper and cite their sources.
TyG index may aid severe AP prognosis prediction; leaves open incremental value over standard scores.
Background: The Triglyceride-glucose (TyG) index is considered to be a simple and reliable surrogate for insulin resistance and an independent predictor of metabolic syndrome. Due to a lack of data on the TyG index in acute pancreatitis (AP). we aimed to investigate the predictive value of the TyG index for the prognosis of severe AP. Methods: The medical data of subjects diagnosed with acute pancreatitis who were hospitalized at Wannan Medical College Yiji Shan Hospital from January 2020 to December 2022 were retrieved from the database and retrospectively analyzed. Patients were divided into two groups according to the Atlanta classification. The TyG index was calculated as follows: ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/ dL)/2]. The major adverse outcome was disease severity, intensive care unit admission, and mortality. Results: A total of 404 patients with acute pancreatitis were included, of whom 59 developed severe acute pancreatitis. The TyG index was higher in the SAP group than in the non-SAP group (8.44 ± 1.53 vs 7.58 ± 1.34, p < 0.05). The area under the TyG index for predicting severe AP was 0.670 (95% CI 0.595 - 0.745, p < 0.05). In multivariate logistic regression, after adjusting for covariates, the TyG index was an independent risk factor for either intensive care unit admission (OR: 1.358, 95% CI: 1.101-1.676, P＜0.05) or severe AP (OR: 1.513, 95% CI: 1.247-1.834, P＜0.05). Conclusions:The TyG index is an independent prognostic factor in patients with acute pancreatitis.
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Sayiti et al. (2023) conducted a cohort in Acute pancreatitis (n=404). Elevated Triglyceride-glucose (TyG) index vs. Lower TyG index was evaluated on Severe acute pancreatitis (OR 1.513, 95% CI 1.247-1.834, p=0.004). An elevated Triglyceride-glucose (TyG) index was independently associated with an increased risk of severe acute pancreatitis (OR 1.513) and ICU admission (OR 1.358).
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